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Our laboratory closes for the holidays on 24th December and will reopen on Friday 3rd January 2025.
Our laboratory closes for the holidays on 24th December and will reopen on Friday 3rd January 2025.
Hereditary Cataracts

Hereditary Cataracts

Turnaround: 1-2 weeks

£48.00 - £48.00
£48.00
£48.00 - £48.00
£48.00

Hereditary Cataracts (HC), or Juvenile Hereditary Cataracts, are a cloudiness of the lens of the eye, causing blurred or lost vision. They develop at an early age (9-15 months) and continue to develop until two to four years, causing blindness if untreated.

An autosomal recessive, or dominant with incomplete penetrance (Australian Shepherd Type), condition caused by a mutation in the HSF4 gene.

Description

Scientific references

Ricketts SL, Pettitt L, McLaughlin B, Jenkins CA, Mellersh CS. A novel locus on canine chromosome 13 is associated with cataract in the Australian Shepherd breed of domestic dog. Mamm Genome. 2015 Jun;26(5-6):257-63

Mellersh CS, Pettitt L, Forman OP, Vaudin M, Barnett KC. Identification of mutations in HSF4 in dogs of three different breeds with hereditary cataracts. Vet Ophthalmol. 2006 Sep-Oct;9(5):369-78