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Paradoxical pseudomyotonia (PP)

Paradoxical pseudomyotonia (PP)

Turnaround: 1-2 weeks

£48.00 - £48.00
£48.00
£48.00 - £48.00
£48.00

We strongly recommend the testing of Cocker Spaniels and Springer Spaniels for this disorder as the incidence is estimated to be 2.5%.

 

Description

PP produces episodes of myotonic-like generalised muscle stiffness after exercise. Episodes generally last less than 45 seconds but there are reports of more severe episodes associated with breathing difficulty (apnoea) and lack of oxygen (cyanosis). 

Scientific references

Van Poucke, M., Stee, K., Lowrie, M., and Peelman, L (2023) The c.126C>A (p.(Cys42Ter)) SLC7A10 nonsense variant is a candidate causative variant for paradoxical pseudomyotonia in English Cocker and Springer Spaniels. Animal Genetics 54:483-490.

Stee, K., Van Poucke, M., Peelman, L., and Lowrie, M. (2020) Paradoxical pseudomyotonia in English Springer and Cocker Spaniels. J. Vet Intern Med 34:253-7.