Curly Coat Dry Eye

Curly Coat Dry Eye (CCDE) causes dry eyes due to abnormal tear production which can lead to eye ulcers. It also causes frizzy hair as well as flaky skin, thickened footpads, and abnormal nails which can make standing and walking painful.

An autosomal recessive condition caused by a mutation in the FAM83H gene.

Forman OP, Penderis J, Hartley C, Hayward LJ, Ricketts SL, Mellersh CS. Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breed. PLoS Genet. 2012 Jan;8(1):e1002462