Canine Multifocal Retinopathy

Canine Multifocal Retinopathy (CMR) is an eye disorder causing degeneration in multiple areas of the retina. Onset is usually between 11 and 16 weeks and is thought generally to not affect vision.

Canine Multifocal Retinopathy is an autosomal recessive condition caused by a mutation in the BEST1 gene.

Guziewicz KE, Aguirre GD, Zangerl B. Modeling the structural consequences of BEST1 missense mutations. Adv Exp Med Biol. 2012;723:611-8

Miyadera K, Acland GM, Aguirre GD. Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies. Mamm Genome. 2012 Feb;23(1-2):40-61